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本文以抗配体抗体免疫组化法检测了３５例胃癌和１９例结肠癌组织中尿型纤溶酶原活化素受体（ｕ－ＰＡＲ），同时也测定了癌基因蛋白Ｃ－ｅｒｂＢ－２表达和组织型纤溶酶原活化素（ｔ一ＰＡ）抗原分布。结果表明ｕ－ＰＡＲ阳性表达多见于癌组织中散在肿瘤细胞表面，胃和结肠癌组织中ｕ－ＰＡＲ阳性表达率分别为２８．６％和３６．８％，Ｃ－ｅｒｂＢ－２分别为３４．３％和４２．１％，这两项指标在浸润型的阳性表达率均显著高于膨胀型（Ｐ０．０５）。经图像分析ｕ－ＰＡＲ和Ｃ－ｅｒｂＢ－２表达间具有相关性（ｒ＝０．８０３。Ｐ＜０．０５），两者与ｔ－ＰＡ抗原分布间均无相关性。上述结果提示ｕ－ＰＡＲ和Ｃ－ｅｒｂＢ－２的阳性表达与肿瘤细胞浸润能力增强可能有关。
In this paper, urinary plasminogen activator receptor (u-PAR) was detected in 35 cases of gastric cancer and 19 cases of colon cancer tissue by immunohistochemical method of anti-ligand antibody. The oncogene protein C-erbB-2 was also measured. Expression and tissue plasminogen activin (t-PA) antigen distribution. The results showed that the positive expression of u-PAR was more common in tumor tissues than in cancerous tissues. The positive expression rates of u-PAR in gastric and colon cancer tissues were 28.6% and 36.8%, respectively, and C-erbB-2 was 34. 3% and 42.1%, the positive rate of these two indicators in infiltrative type were significantly higher than the inflated type (P<0.05). There was a correlation between the expression of u-PAR and C-erbB-2 by image analysis (r=0.803, P<0.05), and there was no correlation between the two and t-PA antigen distribution. The above results suggest that the positive expression of u-PAR and C-erbB-2 may be related to the enhanced infiltration ability of tumor cells.