α-干扰素常用于治疗病毒性疾病及一些肿瘤,已报告的副反应有:发热,寒战,乏力,厌食,肌痛,恶心,呕吐,头痛,剂量依赖可逆性白细胞减少,肝转氨酶升高,蛋白尿,间质性肾炎和肾病综合征。本文报告一例儿童长期应用α-干扰素后发生相似于SLE的综合征。 Commonly used in the treatment of viral diseases and some tumors, alpha-interferon has been reported side effects: fever, chills, fatigue, anorexia, myalgia, nausea, vomiting, headache, dose dependent reversible leucopenia, elevated liver transaminases, Proteinuria, interstitial nephritis and nephrotic syndrome. This article reports a case of children with long-term use of α-interferon similar to SLE syndrome.