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为了减轻激素治疗的副作用 ,我们观察不同剂量甲基强的松龙冲击治疗系统性红斑狼疮 (SLE)血液系统受累的临床疗效。选择具有贫血、白细胞减少、血小板减少之一或两系、三系减少并存SLE患者 45例 ,分 3组 ,分别给予甲基强的松龙 10 0 0mg/d、5 0 0mg/d、12 0mg/d连续 3d冲击治疗。结果 3种剂量甲基强地松龙冲击治疗SLE血液系统受累临床疗效无差别 (P >0 .0 5 ) ,以冲击后第 10天疗效最显著。甲基强地松龙大剂量与中小剂量冲击治疗SLE血液系统受累疗效相同。
In order to alleviate the side effects of hormone therapy, we observed the clinical efficacy of different doses of methylprednisolone impact treatment of systemic lupus erythematosus (SLE) blood system involvement. Forty-five patients with SLE who had anemia, leucopenia and thrombocytopenia and three patients with concurrent thrombocytopenia were divided into three groups and given methylprednisolone (100 mg / d, 500 mg / d, 120 mg / d continuous 3d impact treatment. Results There was no difference in clinical efficacy between the three doses of methylprednisolone in the treatment of SLE blood system involvement (P> 0.05), with the most significant effect on the 10th day after shock. Methylprednisolone large dose and small dose shock treatment of SLE blood system involvement the same effect.