论文部分内容阅读
目的：分析精神分裂症伴迟发性运动障碍( tardive dyskinesia,TD)患者临床脑铁沉积情况,探究二者关系。方法：分别选取82名伴有TD的精神分裂症患者和80例未伴有TD的精神分裂症患者作为研究对象,设为研究组和对照组,利用异常不自主运动量表( AIMS)和磁敏感加权成像技术分别对两组患者的TD状况和基底节灰质核团的校正相对值(CP)进行评定和测定。结果：TD组患者经调整了年龄、药物等因素后黑核和尾状核CP值(-0.197±0.052)rad/(-0.090±0.025)rad]明显较非TD组(-0.161±0.024) rad/(-0.077±0.022)rad低；TD组患者尾状核CP值负相关于AIMS严重程度。结论：基底节区脑铁沉积过载可能导致神经分裂症伴有迟发性运动障碍。“,”To analyze schizophrenia with tardive dyskinesia ( tardive dyskinesia, TD) in patients with clinical y brain iron deposition, explore their relationship. Methods:We selected 82 patients with schizophrenia and 80 TD patients without schizophrenia patients with TD as the research object, set the study group and the control group, the use of abnormal involuntary move-ment scale ( AIMS) and magnetic sensitive weighted imaging technique for correcting TD condition were two groups of patients and basal ganglia gray mat er nuclei relative value ( CP) were as-sessed and measured. The results:TD patients adjusted the black core and caudate nucleus CP values after factors such as age, drugs, etc. [( -0. 197 ± 0. 052) rad / ( -0. 090 ± 0. 025) rad] significantly higher than the non-TD group [( -0. 161 ± 0. 024 ) rad / ( -0. 077 ± 0. 022) rad low;TD caudate nucleus CP patients negative correlation value at AIMS severity. Con-clusion:The basal ganglia iron overload may lead to deposition of schizophrenia with tardive dyskinesia.