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众所周知,蛛网膜下腔出血(SAH)后可引起血管痉挛。迄今为止,尽管有不少研究涉及这一问题,但其机理仍不甚清楚。据报道,在血管平滑肌细胞中,肌动蛋白和肌球蛋白控制着收缩过程,但必须有一定的自细胞外向细胞内的的信号传递。蛋白激酶 C(PKC)是一种对钙易感的蛋白激酶。作者以往所进行的等张试验发现,当 PKC 被激活时,犬的基底动脉发生明显而持久的收缩,从而表明 PKC 在血管痉挛的信号传递中起着关键作用。作者称此假设为诱导作用。为证实这一假说的成立,作者进行
As we all know, subarachnoid hemorrhage (SAH) can cause vasospasm. To date, although many studies have dealt with this issue, the mechanism remains unclear. It has been reported that actin and myosin control the process of contraction in vascular smooth muscle cells but must have some signal transduction from the extracellular to the intracellular. Protein kinase C (PKC) is a protein kinase susceptible to calcium. The authors conducted isotonic experiments in the past to find that when PKC is activated, significant and long-lasting contraction of the canine basilar artery occurs, indicating that PKC plays a key role in the signal transduction of vasospasm. The authors call this hypothesis as an inducing effect. To confirm the establishment of this hypothesis, the author conducted