ｘｙ１Ｅ－ＩＣＲ转基因小鼠突变检测模型不仅可用于体内基因突变研究，还可以在同一动物体内同时进行多个遗传学终点的比较分析工作。本研究将遗传毒性致癌物乙基亚硝基脲（ＥＮＵ）作用于雄性转基因小鼠，研究其对精子形态的影响。选用６－８周龄Ｆ１代ｘｙ１Ｅ－ＩＣＲ转基 xy1E-ICR transgenic mice mutation detection model can be used not only in vivo gene mutation studies, but also in the same animal body multiple simultaneous analysis of genetic endpoints. In this study, genotoxicity carcinogen ethyl nitrosourea (ENU) was applied to male transgenic mice to study their effects on the morphology of sperm. 6-8 weeks old F1 generation xy1E-ICR translocation