论文部分内容阅读
实验制成大鼠肝硬化门脉高压（PHT）缺血再灌注模型，用电子自旋共振技术测定缺血再灌注前后及丹参治疗后胃粘膜中氧自由基（OFR）以及脂质过氧化物（LPO）和超氧化物歧化酶（SOD）的变化，同时光镜、电镜观察其病理改变，探讨丹参对胃粘膜再灌注损伤的防治作用。实验结果提示：PHT胃粘膜较正常胃粘膜更易受缺血再灌注损伤，粘膜损伤的严重程度与OFR、LPO及SOD密切相关；早期使用丹参可显著降低胃粘膜中OFR及LPO含量，提高SOD活性，减轻胃粘膜掼伤，起到保护胃粘膜的作用。
The model of ischemia-reperfusion in rat cirrhotic portal hypertension (PHT) was established. The electron spin resonance technique was used to determine the content of oxygen free radical (OFR) and lipid peroxidation in gastric mucosa before and after ischemia reperfusion (LPO) and superoxide dismutase (SOD). The pathological changes were observed under light microscope and electron microscope, and the preventive and therapeutic effects of radix salviae miltiorrhizae on gastric mucosal reperfusion injury were discussed. The results suggest that: PHT gastric mucosa is more vulnerable to ischemia-reperfusion injury than normal gastric mucosa, the severity of mucosal injury and OFR, LPO and SOD are closely related; early use of Salvia can significantly reduce the content of OFR and LPO in gastric mucosa, increase SOD activity , Reduce gastric mucosal injury, play a role in protecting the gastric mucosa.