目的:观察涤痰汤合小陷胸汤对慢性支气管哮喘患者气道炎症及重塑的影响慢性。方法:选取90慢性例痰热壅肺证慢性支气管炎患者为研究对象,随机数字表法分为联合组和对照组各45例。对照组予以西药(头孢吡肟)治疗;联合组予以西药联合加减涤痰汤和小陷胸汤治疗。观察对比两组患者症状缓解时间、X线示肺部阴影消失时间及总住院时间差异,记录其治疗前后气道重塑指标[气道壁面积(WA)、气道壁面积占气道总面积百分比(WA%)]、T淋巴细胞亚群(CD_3~+、CD_4~+、CD_8~+)及炎症指标[白细胞计数(WBC)、C反应蛋白(CRP)]变化差异,分析不良反应发生情况。结果:联合组咳嗽、喘憋、发热、肺部干湿啰音等症状缓解时间、X线示肺部阴影消失时间及总住院时间均显著低于对照组(P<0.05)。治疗后,两组CD_3~+、CD_4~+等T淋巴细胞亚群检测结果均较治疗前显著提高,且联合组>对照组;气道重塑指标(WA、WA%)、相关炎症指标(WBC、CRP)及CD_8~+检测结果则较治疗前显著降低,且联合组<对照组,差异均有统计学意义(P<0.05)。结论涤痰汤合小陷胸汤可在痰热壅肺证的慢性支气管炎患者临床治疗中发挥积极作用,对抑制气道重塑、缓解气道炎症反应等有利。 Objective: To observe the effect of Ditan Decoction and Xiaoxianxiong Decoction on airway inflammation and remodeling in patients with chronic bronchial asthma. Methods: Ninety patients with chronic bronchitis with chronic phlegm and phlegm-heat syndrome were enrolled in this study. The random number table was divided into 45 cases in each group. The control group was given western medicine (cefepime) treatment; the combination group was treated with western medicine combined with Ditan decoction and Xiaoxianxiong decoction. Observed and compared the two groups of patients with symptom relief time, X-ray showed the disappearance of lung shadow time and total hospital stay, recorded before and after treatment of airway remodeling indicators [airway wall area (WA), airway wall area accounted for the total airway area (WA%), T lymphocyte subsets (CD_3 ~ +, CD_4 ~ +, CD_8 ~ +) and inflammatory markers [WBC and C-reactive protein (CRP)] were analyzed. The incidence of adverse reactions . Results: The relief time of cough, wheezing, fever, dry-wet rales of the lungs and other symptoms in the combined group were significantly lower than those in the control group (P <0.05). After treatment, the detection results of T lymphocyte subgroups such as CD_3 ~ +, CD_4 ~ + in both groups were significantly higher than those before treatment, and the combined group> control group; airway remodeling index (WA, WA% WBC, CRP) and CD_8 ~ + test results were significantly lower than before treatment, and the combined group