Objectives: Validated, noninvasive studies were used to compare sensation and motor function of the upper gastrointestinal tract in adolescents with function al dyspepsia (FD) and in control subjects. Study design: Fifteen adolescents with FD and 15 healthy participants underwent standardized symptom assessment, a sa tiation nutrient drink test, and 13C- Spirulina platensis breath test for gastr ic emptying of solids. Adolescents with FD also underwent measurements of fastin g and postprandial gastric volume by means of single- photon emission computed tomography, and their results were compared with those from 15 healthy volunteer s (age, 18 to 25 years). Results: Compared with control subjects, adolescents wi th FD had significantly higher postprandial symptoms 30 minutes after reaching m aximum satiation with the nutrient drink test and significant delay in the T1/2 for gastric emptying of solids. Compared with healthy 18- to 25- year- old ad ults, adolescents had a diminished postprandial gastric volume response. By mean s of single- photon emission computed tomography, frequent baseline dyspeptic s ymptoms were associated with prolonged T1/2 for gastric emptying and higher post prandial aggregate symptom score. A baseline increased severity of dyspepsia sym ptoms was associated with prolonged T1/2 for gastric emptying. Conclusions: Adol escents with FD demonstrate increased postprandial symptoms after challenge,dela yed gastric emptying, and a reduced gastric volume response to feeding. Objectives: Validated, noninvasive studies were used to compare sensation and motor function of the upper gastrointestinal tract in adolescents with function al dyspepsia (FD) and in control subjects. Study design: Fifteen adolescents with FD and 15 healthy participants underwent standardized symptom assessment, a sa tiation nutrient drink test, and 13C- Spirulina platensis breath test for gastr ic emptying of solids. Adolescents with FD also underwent measurements of fastin g and postprandial gastric volume by means of single- photon emission computed tomography, and their results were compared that Results: Compared with control subjects, adolescents wi th FD had significantly higher postprandial symptoms 30 minutes after reaching m aximum satiation with the nutrient drink test and significant delay in the T1 / 2 for gastric emptying of solids. Compared with healthy 18- to 25- year- old ad ults, adolescents had a diminished postp rand mean gastric volume response. By mean s of single-photon emission computed tomography, frequent baseline dyspeptic s ymptoms were associated with prolonged T1 / 2 for gastric emptying and higher post prandial aggregate symptom score. A baseline increased severity of dyspepsia sym ptoms was associated with prolonged T1 / 2 for gastric emptying. Conclusions: Adol escents with FD demonstrated increased postprandial symptoms after challenge, dela yed gastric emptying, and reduced gastric volume response to feeding.