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ATP敏感性钾通道 (KATP)是缺血预适应的重要环节 ,但KATP介导缺血预适应的作用位点是在心肌细胞膜还是在线粒体尚有争议。本文就线粒体KATP的结构 ,功能和在缺血预适应中的作用与机制作一综述。
ATP-sensitive potassium channel (KATP) is an important part of ischemic preconditioning. However, it is still controversial whether KATP mediates the role of ischemic preconditioning in myocardial cell membrane or in mitochondria. This review summarizes the structure and function of mitochondrial KATP and their roles and mechanisms in ischemic preconditioning.