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本文阐述了用高效液相色谱法测定静脉推注泰必利与正常人口服泰必利水溶液的药物动力学结果。口服该药的血浓度及尿浓度数据按线性一室模型处理;静脉推注数据按线性二室模型处理。该药国产原料相对于法国原料的生物利用度为96％,它在尿中以原形排泄的百分率为81％,国产泰必利与法国产品的药物动力学参数基本一致。
This article describes the pharmacokinetic results of oral tiapride and oral administration of tiapride in aqueous solution by high performance liquid chromatography. Oral administration of the drug’s blood concentration and urine concentration data by a linear one-compartment model; intravenous bolus data by linear two-compartment model. The bioavailability of the drug-made raw material relative to the French raw material was 96%, and it was 81% in the urine as a matter of principle. The pharmacokinetic parameters of the domestic tiapride and the French product were basically the same.