病例组为从比利时3个工业区选取的272名慢性肾功能衰竭患者(男性159人,女性113人,平均年龄59.9岁,个人资料均详细、可靠)。其中81例(29.8%)为透析病人,其人口统计学特征与非透析病人一致。按照年龄、性别、居住地匹配272名肾功正常者组成对照组;病例组(不计透析病人)平均血清肌酐水平为327μmol/L,肌酐清除率为28.2ml/min。流行病学调查 The case group consisted of 272 patients with chronic renal failure (159 males and 113 females, mean age 59.9 years) selected from three industrial districts in Belgium. The personal data were both detailed and reliable. Of these, 81 (29.8%) were dialysis patients and their demographic characteristics were consistent with those of non-dialysis patients. According to the age, sex and place of residence, 272 normal controls were matched. The average serum creatinine level was 327μmol / L in the case group (excluding dialysis patients) and 28.2ml / min in creatinine. Epidemiological Investigation