背景 人类中性粒细胞抗原-2a(NB1)位于NB1糖蛋白上,它在中性粒细胞分组上表达。PRV-1是一个在红细胞增多症病人的中性粒细胞上过度表达的基因。NB1的基因编码与PRV-1的区别在4个核苷酸上。本研究的目的在于测定NB1与PRV-1究竟是同一个基因的等位基因,还是两个不同的基因;如果它们是等位基因,揭示与NB1糖蛋白表达的可能的联系。研究设计和方法 运用引物对在4个NB1多形态性位点 Background Human neutrophil antigen-2a (NB1) is located on the NB1 glycoprotein and is expressed on the neutrophil subgroup. PRV-1 is a gene overexpressed on neutrophils in patients with polycythemia. The gene encoding NB1 differs from PRV-1 by 4 nucleotides. The purpose of this study was to determine whether NB1 and PRV-1 are alleles of the same gene or two different genes; if they are alleles, it is possible to reveal a possible association with NB1 glycoprotein expression. The study design and methodology used primer pairs at 4 NB1 polymorphic loci