论文部分内容阅读
目的探讨食管癌组织中PTEN和Livin蛋白的表达及其临床意义。方法用免疫组化方法检测200例食管癌患者(A组)和30例正常食管组织(B组)PTEN和Livin蛋白表达。结果 A组PTEN蛋白的阳性表达率低于B组(38.0%vs.93.3%)(P<0.05),而Livin蛋白的阳性表达率高于B组(72.5%vs.23.3%)(P<0.05)。A组PTEN和Livin蛋白的表达与淋巴结转移、肿瘤分化程度和临床分期有关(P<0.05),PTEN和Livin蛋白表达呈负相关(r=-0.427,P<0.05)。结论 PTEN和Livin的异常表达可能参与了食管癌的发生、发展;两者联合检测有可能成为食管癌分级、预后评估的新分子标记物。
Objective To investigate the expression of PTEN and Livin in esophageal carcinoma and its clinical significance. Methods The expressions of PTEN and Livin in 200 esophageal cancer patients (group A) and 30 normal esophageal tissues (group B) were detected by immunohistochemistry. Results The positive expression rate of PTEN protein in group A was lower than that in group B (38.0% vs 93.3%, P <0.05), while the positive expression rate of Livin protein was higher than that in group B (72.5% vs.23.3% ). The expression of PTEN and Livin in group A was correlated with lymph node metastasis, tumor differentiation and clinical stage (P <0.05), but negatively correlated with PTEN and Livin protein expression (r = -0.427, P <0.05). Conclusions The abnormal expression of PTEN and Livin may be involved in the occurrence and development of esophageal cancer. The combined detection of PTEN and Livin might be a new molecular marker for esophageal cancer grading and prognosis evaluation.