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目的探讨肿瘤相关糖蛋白-72(TAG-72)在卵巢癌组织中的表达与意义。方法采用免疫组织化学法检测50例卵巢癌及20例正常卵巢组织中TAG-72的表达情况,并结合临床病理因素进行分析。结果 TAG-72在卵巢癌组织中的表达率(26.0%)明显高于正常卵巢组织(0)(P<0.05),其表达与肿瘤临床分期、组织分化程度有关。结论 TAG-72的高表达与卵巢癌的发生、发展和生物学行为密切相关,因此其在卵巢癌的肿瘤标记与早期诊断方面具有重要的意义。
Objective To investigate the expression of tumor associated glycoprotein-72 (TAG-72) in ovarian cancer and its significance. Methods Immunohistochemical method was used to detect the expression of TAG-72 in 50 cases of ovarian cancer and 20 cases of normal ovarian tissue, and analyzed with clinicopathological factors. Results The positive rate of TAG-72 in ovarian cancer tissues (26.0%) was significantly higher than that in normal ovarian tissues (0) (P <0.05). The expression of TAG-72 was correlated with clinical stage and histological differentiation. Conclusion The high expression of TAG-72 is closely related to the occurrence, development and biological behavior of ovarian cancer. Therefore, TAG-72 is of great significance in tumor marker and early diagnosis of ovarian cancer.