2型糖尿病病人磺脲类药物继发性失效是临床较常见的问题,需应用胰岛素治疗,我们应用诺和灵N(低精蛋白锌人胰岛素)联合二甲双胍治疗此类病人40例,血糖控制明显改善,疗效显著,现报告如下。1资料与方法1.1一般资料所有病人根据WHO 1999年诊断标准确诊为2型糖尿病,磺脲类药物继发性 Secondary failure of sulfonylureas in patients with type 2 diabetes is a more common clinical problem, the need for insulin treatment, we use noradrenaline N (low-protein zinc insulin in patients with metformin) metformin 40 cases of such patients, blood glucose control significantly Improvement, significant effect, are as follows. 1 Materials and Methods 1.1 General Information All patients diagnosed in accordance with WHO 1999 diagnostic criteria for type 2 diabetes, sulfonylurea secondary