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目的 探讨老龄大鼠慢性脑灌注脑损害和认知功能障碍及其机制。方法 5 0只老龄大鼠用于实验 ,其中 2 0只接受环孢菌素A(CsA)胃灌治疗。用光镜和电镜观察组织学改变 ,免疫组织化学法检测免疫细胞的活动 ,采用微机控制穿梭箱双向主动回避反应实验系统检测大鼠认知功能。结果 大鼠持久性双侧颈总动脉结扎 (2VO)诱导的慢性脑灌注不足造成了脑组织广泛免疫细胞活动和进行性脑损害 ,导致了大鼠进行性学习和记忆能力下降。CsA治疗组大鼠脑内免疫细胞的活动明显减少 ,脑损害明显减轻 ,学习和记忆能力显著提高。结论 脑组织免疫细胞的活动贯穿于大鼠慢性脑灌注不足脑损害的病理过程 ,在脑损害和认知功能障碍的发生和发展中起重要作用 ;CsA可明显减轻脑内免疫细胞的活动 ,防治了大鼠的脑损害和认知功能障碍。
Objective To investigate the chronic brain injury and cognitive impairment in aging rats and its mechanism. Methods Fifty aged rats were used in the experiment, 20 of them received cyclosporine A (CsA) gastric perfusion. Histological changes were observed with light microscope and electron microscope. Immunohistochemistry was used to detect the activity of immune cells. The cognitive function of rats was detected by two-way active avoidance reaction system of computer controlled shuttle box. Results Insufficient chronic cerebral hypoperfusion induced by persistent bilateral common carotid artery ligation (2VO) in rats resulted in extensive immune cell activity and progressive brain damage in the brain, leading to progressive learning and memory impairment in rats. The activity of immune cells in the brain of CsA treatment group was significantly reduced, the brain damage was significantly reduced, and the learning and memory ability was significantly increased. Conclusion The activity of immune cells in brain tissue runs through the pathological process of brain damage caused by chronic cerebral hypoperfusion in rats and plays an important role in the development of brain damage and cognitive impairment. CsA can obviously reduce the activity of immune cells in the brain, Rat brain damage and cognitive dysfunction.