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目的探讨妊娠期糖尿病(GDM)患者血清同型半胱氨酸(Hcy)与APN水平的变化。方法选取GDM患者46例,另选同期正常妊娠妇女46名为健康对照(NC)组,比较两组Hcy及APN水平。结果 GDM组Hcy[(13.5±4.6)vs(8.6±3.7)μmol/L]、FPG[(8.4±2.8)vs(5.5±1.3)mmol/L]水平均高于NC组(P<0.05),APN[(7.6±2.4)vs(16.9±4.2)mg/L]水平低于NC组(P<0.05)。FPG与Hcy和APN均呈中度相关。结论 GDM患者Hcy水平高于正常妊娠者,APN水平低于正常妊娠者。Hcy与APN水平呈负相关。
Objective To investigate the changes of serum homocysteine (Hcy) and APN levels in patients with gestational diabetes mellitus (GDM). Methods Forty-six patients with GDM and 46 healthy controls were enrolled in this study. The levels of Hcy and APN were compared between the two groups. Results The levels of Hcy [(13.5 ± 4.6) vs (8.6 ± 3.7) μmol / L and FPG [8.4 ± 2.8 vs 5.5 ± 1.3 mmol / L] were significantly higher in NC group than those in NC group The level of APN [(7.6 ± 2.4) vs (16.9 ± 4.2) mg / L] was lower than that of NC group (P <0.05). FPG was moderately correlated with Hcy and APN. Conclusion The Hcy level in patients with GDM is higher than that in normal pregnancy, and the APN level is lower than that in normal pregnancy. Hcy and APN levels were negatively correlated.