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目的探讨地方性砷中毒对机体氧化应激反应的远期影响,为砷中毒病区居民的预防和治疗提供科学依据。方法采用整群抽样和典型调查相结合的方法进行现场调查,改水5年后的砷中毒病区调查者分为轻、中、重度病例组和内对照组,非病区调查者为外对照组。对调查者的氧化应激指标即超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)进行测定和分析,用SPSS13.0 for windows软件对数据进行统计分析处理。结果本次调查了5个组共252人,所选择的病区村5年前已实施改水,水砷含量符合国家标准(≤0.05 mg/L),各组尿砷含量无显著差异(H=2.698,P>0.05)。各组SOD活力差异显著(F=52.42,P<0.01),外对照组明显高于其他组(P<0.05或P<0.01),内对照组高于病例组(P<0.01),各病例组间无显著差异(P>0.05);各组GSH-Px活力无显著差异(H=4.209,P>0.05);各组MDA含量差异显著(F=3.36,P<0.05),外对照组明显低于其他组(P<0.05或P<0.01),其他组间比较无差异(P>0.05)。结论地方性砷中毒患者饮用低砷水5年后砷对机体的氧化应激反应影响仍然存在,砷中毒病区在加大除砷改水力度的同时,应加强居民身体状况的监测。
Objective To explore the long-term effects of endemic arsenism on the oxidative stress response in the organism and provide a scientific basis for the prevention and treatment of residents with arsenic poisoning. Methods The method of cluster sampling and typical survey was used to carry out on-the-spot investigation. The arsenic poisoning ward surveyers who changed water five years later were divided into mild, moderate and severe cases group and control group. The non-ward investigators were external control group. Oxidative stress indicators such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were measured and analyzed. SPSS 13.0 for windows software The data for statistical analysis. Results A total of 252 patients were selected from 5 groups. The selected ward villages had been rehabilitated five years ago. The arsenic content of the water met the national standard (≤0.05 mg / L), and there was no significant difference in urinary arsenic content between the groups = 2.698, P> 0.05). The activity of SOD in each group was significantly different (F = 52.42, P <0.01), that of the control group was significantly higher than that of the other groups (P <0.05 or P <0.01) There was no significant difference between the two groups (P> 0.05). The activity of GSH-Px in each group had no significant difference (H = 4.209, P> 0.05) In the other groups (P <0.05 or P <0.01), the other groups showed no difference (P> 0.05). CONCLUSIONS: After 5 years of drinking low-arsenic water in endemic arsenism patients, the influence of arsenic on the oxidative stress reaction of arsenic still exists in the arsenic poisoning patients. While arsenic poisoning endeavors should intensify efforts to remove arsenic, it should strengthen the monitoring of residents’ physical status.