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目的：探讨内皮素在脑缺血疾患中的发病学意义及牛磺酸对脑缺血疾患的治疗机制。方法：在脑血栓病人和大鼠脑（缺血／再灌注）模型上观察内皮素的变化和牛磺酸的治疗作用。结果：脑缺血过程中内皮素水平显著增高，内皮素增加与脑组织损伤呈正相关。牛磺酸能显著减轻脑组织缺血损伤，抑制内皮素增加。结论：内皮素在脑缺血过程中具有重要发病学意义。牛磺酸抑制内皮素增加可能是其减轻脑缺血损伤机制之一。
Objective: To investigate the pathogenetic significance of endothelin in cerebral ischemic disorders and the mechanism of taurine in treating cerebral ischemic disorders. Methods: The changes of endothelin and taurine were observed in the brain and cerebral ischemia / reperfusion model in rats. Results: Endothelin level was significantly increased during cerebral ischemia, and increased endothelin was positively correlated with brain injury. Taurine can significantly reduce the ischemic injury of brain tissue and inhibit the increase of endothelin. Conclusion: Endothelin plays an important role in cerebral ischemia. Taurine inhibits the increase of endothelin may be one of its mechanisms to reduce cerebral ischemia injury.