论文部分内容阅读
目的探讨血管内皮生长因子C(VEGF-C)和ATP结合转运蛋白G超家族成员2(PCNA)在胃癌组织中的表达及意义。方法应用免疫组化SP法检测216例胃癌和160例胃溃疡等手术者的胃组织中VEGF-C和PCNA的表达。结果 VEGF-C在对照组阳性率为15.0%(24/160),实验组为48.6%(105/216),差异有统计学意义(χ2=46.07,P<0.0001);PCNA在对照组阳性率为16.9%(27/160),实验组为47.7%(103/216),差异有统计学意义(χ2=38.57,P<0.0001)。VEGF-C和PCNA的阳性表达与性别、年龄、肿瘤大小和组织学类型无关(P>0.05);VEGF-C和PCNA的阳性表达与肿瘤的分化程度、浸润深度、是否淋巴结转移和TNM分期密切相关(P<0.01或0.05)。VEGF-C表达和PCNA的表达密切正相关(P<0.01)。结论 VEGF-C和PCNA的表达程度,可作为评估胃癌转移的一个观测指标和治疗靶点。
Objective To investigate the expression and significance of vascular endothelial growth factor C (VEGF-C) and ATP-binding transport protein G superfamily member 2 (PCNA) in gastric cancer. Methods The expression of VEGF-C and PCNA in gastric tissues of 216 gastric cancer patients and 160 gastric ulcer patients were detected by immunohistochemical SP method. Results The positive rate of VEGF-C in the control group was 15.0% (24/160) and in the experimental group was 48.6% (105/216), the difference was statistically significant (χ2 = 46.07, P <0.0001) , 16.9% (27/160) in experimental group and 47.7% (103/216) in experimental group. The difference was statistically significant (χ2 = 38.57, P <0.0001). The positive expression of VEGF-C and PCNA was not related to gender, age, tumor size and histological type (P> 0.05). The positive expression of VEGF-C and PCNA correlated with tumor differentiation, depth of invasion, lymph node metastasis and TNM staging (P <0.01 or 0.05). The expression of VEGF-C was positively correlated with the expression of PCNA (P <0.01). Conclusions The expression of VEGF-C and PCNA can be used as an observation target and therapeutic target for the assessment of gastric cancer metastasis.