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目的探讨益生菌肠内营养治疗重症急性胰腺炎(SAP)的临床效果。方法将2013年7月至2014年12月福建省立医院收治的96例SAP患者分为益生菌肠内营养组(观察组)和常规治疗组(对照组),每组48例。比较两组患者住院天数、腹痛消失时间、CRP恢复时间、血淀粉酶恢复时间、感染率、并发症发生率以及肠内菌群变化情况。结果治疗后观察组与对照组比较,患者平均住院天数、腹痛消失时间、CRP恢复时间及血淀粉酶恢复时间均缩短(P<0.05),且感染发生率及并发症的发生率均降低,差异有统计学意义(P<0.05)。观察组患者肠道双歧杆菌、乳杆菌的总数较治疗前显著提高(P<0.05)。结论早期应用益生菌辅助治疗SAP可有效调节肠道菌群微生态平衡,降低SAP肠黏膜损伤,保护肠屏障功能,进而改善其病程及预后。
Objective To investigate the clinical efficacy of probiotics in the treatment of severe acute pancreatitis (SAP). Methods 96 cases of SAP patients admitted to Fujian Provincial Hospital from July 2013 to December 2014 were divided into probiotics enteral nutrition group (observation group) and conventional treatment group (control group), 48 cases in each group. The days of hospitalization, the disappearance of abdominal pain, the recovery time of CRP, the recovery time of blood amylase, the infection rate, the incidence of complications and the changes of intestinal flora were compared between the two groups. Results Compared with the control group, the average days of hospitalization, the disappearance of abdominal pain, the recovery time of CRP and the recovery time of blood amylase in both observation group and control group were shortened (P <0.05), and the incidence of infection and complication rate were also decreased There was statistical significance (P <0.05). The total number of intestinal bifidobacteria and lactobacilli in observation group was significantly higher than that before treatment (P <0.05). Conclusions The early application of probiotics in the treatment of SAP can effectively regulate the microecological balance of intestinal microflora, reduce the intestinal mucosal injury of SAP, and protect the intestinal barrier function, thereby improving its course and prognosis.