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用多聚酶链反应—限制性内切酶片段长度多态性技术(PCR-RFLP),对403例冠心病的患者和400例无心脏病史的健康体检者进行kozak序列-5T/C多态性检测。结果冠心病组C/C基因型频率为7.7%,高于对照组的4.0%,P<0.05,比值比(OR)为2.0,95%可信区间为1.1~3.7。认为血小板GPⅠbα基因kozak序列-5T/C多态性与冠心病之间存在相关性;kozak序列-5T/C多态性可能为冠心病发生的一种遗传易感性标志。
Using PCR-RFLP, kozak sequence-5T / C polymorphism was detected in 403 patients with coronary heart disease and 400 healthy subjects without history of heart disease . Results The frequency of C / C genotype in CHD group was 7.7%, which was higher than that in control group (P <0.05). The odds ratio (OR) was 2.0, and the 95% confidence interval was 1.1-3.7. It is considered that there is a correlation between kozak sequence -5T / C polymorphism of GPⅠbα gene and coronary heart disease. Kozak sequence -5T / C polymorphism may be a genetic susceptibility marker for coronary heart disease.