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HIV疫苗研究的巨大障碍在于目前设计的包含Env蛋白或表位的疫苗在临床前及临床试验中难于诱导产生广谱中和抗体。近来的研究表明一些HIV-1感染者血清中存在的抗体能够中和多种病毒株,而新的表位作图技术对这些广谱中和血清表位特异性的深入分析将对广谱中和抗体靶向的病毒表位提供新的线索。通过广谱中和血清表位特异性研究获得的信息将促进新的广谱中和单克隆抗体的分离和潜在新表位的鉴定,为合理设计新的疫苗免疫原提供关键信息。
A significant hurdle in HIV vaccine research is that currently designed vaccines that contain Env proteins or epitopes are difficult to induce in a preclinical and clinical trial to produce broad-spectrum neutralizing antibodies. Recent studies have shown that antibodies present in the sera of some HIV-1 infected patients are capable of neutralizing a number of viral strains, and the new epitope mapping technique. The in-depth analysis of these broad-spectrum neutralizing serum epitopes will be of particular value in broad spectrum And antibody-targeted viral epitopes provide new clues. The information gained through broad-spectrum neutralization of serum epitope-specific studies will facilitate the isolation of new broad-spectrum neutralizing monoclonal antibodies and the identification of potential neoepitopes, providing critical information for the rational design of novel vaccine immunogens.