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本文观察不同剂量乙肝疫苗对儿童５５个月后的免疫效果。小剂量组９８人，剂量５ｕｇ×３次；对照组１３６人，剂量３０ｕｇ、１０ｕｇ、１０ｕｇ。于０、１、６月三角肌部位注射。同时观察未接种乙肝疫苗儿童１７６人ＨＢＶ感染情况。结果；首剂接种８、１８、５５个月后，抗－ＨＢｓ≥１０ｍＩｕｕ／ｍｌ的人数，小剂量组和对照组分别为５０／５４对５７／５８（Ｐ＞０．０５）；５２／５３及５４／５５（Ｐ＞０．０５）；３６／４１对７３／７８ｐ＜０．０５）。两组抗－ＨＢｓ几何平均滴度（ＧＭＴ）分别为３４±０．２７对５５．４±０．４２（ｐ＜０．０１）；４２．０对５５．０（ｐ＜０．０５）；７６．１４对１３９．５（ｐ＞０．０５）。５５个月两组无显著性差异。所有接种儿童，不论抗－ＨＲｓ滴度是否达到有效保护水平，ＨＢ、Ａｇ均阴性。未按种儿童ＨＢｓＡｇ（＋）为１１／１７６（６．２５％）。结论：与正规剂量一样，小剂量乙肝疫苗同样产生有效的保护作平，接种后机－ＨＢｓ低滴度儿童仍可防止ＨＢＶ感染。
This article observed different doses of hepatitis B vaccine in children after 55 months of immune effect. Small dose group of 98 people, the dose of 5ug × 3 times; control group of 136 people, the dose of 30ug, 10ug, 10ug. In 0, 1, 6 months deltoid parts of the injection. At the same time, 176 HBV infected children who did not receive hepatitis B vaccine were observed. Results: The number of anti-HBs≥10 mIuu / ml in the low-dose group and the control group were 50/54 vs 57/58 (P> 0.05), 52/53 And 54/55 (P> 0.05); 36/41 vs 73/78 p <0.05). The geometric mean titers (GMTs) of anti-HBs in the two groups were 34 ± 0.27 vs 55.4 ± 0.42 (p <0.01), 42.0 vs 55.0 (p <0.05), respectively. 76.14 vs 139.5 (p> 0.05). 55 months there was no significant difference between the two groups. All vaccinated children, regardless of anti -HRs titers reached the level of effective protection, HB, Ag were negative. Uncultivated children HBsAg (+) was 11/176 (6.25%). CONCLUSIONS: As with regular doses, low-dose hepatitis B vaccines also produce potent protection levels, and post-vaccination children with low-titer HBs can still prevent HBV infection.