【摘 要】
：
目的 研究受1Gyγ射线照射后一个月,C57小鼠胸腺细胞细胞基因表达谱的变化.方法 使用Agilent小鼠oligo基因芯片技术,观察受照射小鼠和非受照射小鼠两组间的基因差异表达.结果
【机 构】
：
第二军医大学海军医学系放射医学教研室,上海,200433;
论文部分内容阅读
目的 研究受1Gyγ射线照射后一个月,C57小鼠胸腺细胞细胞基因表达谱的变化.方法 使用Agilent小鼠oligo基因芯片技术,观察受照射小鼠和非受照射小鼠两组间的基因差异表达.结果 在所观察小鼠21319个基因中,107个基因在受照射小鼠胸腺组织中表达上调2倍以上(其中13个上调4倍以上),9个基因表达下调超过200%(其中2个下调超过400%),这些变化基因涉及细胞的一些基本代谢活动.结论 变化明显的基因功能涉及胚胎发育,组织形成与维持,免疫与应激、蛋白合成、凋亡、信号转导等,上调基因的数量远多于下调基因数量,其中编码角蛋白在胚胎发育中的作用值得注意.在变化明显的上调和下调基因功能中都涉及到PI3-K,也是一个值得继续关注的现象.
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