论文部分内容阅读
目的：了解巯甲丙脯酸、酚妥拉明、多巴胺、硝苯地平和山莨菪碱对肾综合征出血热（ＨＦＲＳ）患者肾功能的影响，为临床选择改善肾功能的药物提供依据。方法：选择ＨＦＲＳ患者２１０例，随机分为巯甲丙脯酸组、酚妥拉明组、多巴胺组、硝苯地平组、山莨菪碱组和对照组，每组３５例。对照组仅用综合治疗法，其余各组均在综合治疗的基础上分别加用上述药物。结果：巯甲丙脯酸组、酚妥拉明组、多巴胺组、硝苯地平组、山莨菪碱组在尿蛋白消失时间、尿素氮复常时间、少尿期发生率、少尿期和多尿期持续时间方面均优于对照组，尤以巯甲丙脯酸组和酚妥拉明组最为明显。结论：巯甲丙脯酸、酚妥拉明、硝苯地平、多巴胺和山莨菪碱能促进ＨＦＲＳ患者肾功能的恢复，而以巯甲丙脯酸和酚妥拉明为优。提示ＨＦＲＳ患者可常规应用巯甲丙脯酸、酚妥拉明、硝苯地平、多巴胺和山莨菪碱；对于重症患者，可联合应用２种～３种上述药物。
Objective: To investigate the effects of captopril, phentolamine, dopamine, nifedipine and anisodamine on renal function in patients with hemorrhagic fever with renal syndrome (HFRS), and to provide basis for clinical choice of drugs to improve renal function. Methods: A total of 210 HFRS patients were randomly divided into captopril group, phentolamine group, dopamine group, nifedipine group, anisodamine group and control group, 35 cases in each group. The control group only with comprehensive treatment, the remaining groups were based on the comprehensive treatment were added with the above drugs. Results: There was no significant difference in urinary albumin disappearance time, urea nitrogen recovery time, incidence of oliguria, oliguria, and more in the captopril group, the phentolamine group, the dopamine group, the nifedipine group and the anisodamine group Urinary duration were better than the control group, especially in captopril and phentolamine group the most obvious. CONCLUSIONS: Captopril, phentolamine, nifedipine, dopamine and anisodamine promote renal function recovery in patients with HFRS, with captopril and phentolamine as the best. Tip HFRS patients can be routinely used captopril, phentolamine, nifedipine, dopamine and anisodamine; for critically ill patients, can be combined with 2 to 3 kinds of the above drugs.