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目的 探讨产超广谱 β-内酰胺酶 (ESBL s)菌株医院感染的危险因素。方法 对医院 2 0 0 0年 7～ 12月间 5 2例患者 ESBL s阳性引发医院感染的危险因素进行 1∶ 1病例对照研究。结果 产 ESBL s菌株引发医院感染率占34.90 % ,病死率为 5 .76 % ;感染部位以下呼吸道和泌尿道为主 ;发生医院感染的危险因素 L ogistic回归分析为呼吸道插管、泌尿道插管、免疫抑制药、第三代头孢菌素使用。结论 有上述危险因素存在的患者要严密监测有无感染发生 ,缩短住院时间 ,尽量减少插用导尿管及其他插管 ,谨慎应用第三代头孢菌素和免疫抑制剂均可减少感染的发生。
Objective To investigate the risk factors of nosocomial infection of extended-spectrum β-lactamases (ESBLs) strains. Methods A 1: 1 case-control study was conducted on the risk factors of nosocomial infection in ESBL-positive patients in 52 cases from July to December in the hospital. Results The prevalence of nosocomial infection in ESBLs strains was 34.90% and the case fatality rate was 5.76%. The respiratory tract and urinary tract below the infected sites were the major ones. The logistic regression analysis of risk factors for nosocomial infections was respiratory tract and urinary tract intubation , Immunosuppressive drugs, the third generation cephalosporins use. Conclusions Patients with the above risk factors should be closely monitored for occurrence of infection, shortening the length of hospital stay, minimizing catheterization and other intubation, and prudent application of third generation cephalosporins and immunosuppressive agents may reduce the incidence of infection .