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目的:探究前列地尔对高龄糖尿病合并慢性肾脏病患者的治疗疗效以及不良反应情况。方法:按照随机数字表法将2015.5-2016.5入诊我院进行治疗的104例糖尿病合并慢性肾脏病的患者分为A、B两组各52例,所有患者年龄均高于60岁,其中A组进行临床常规治疗,B组在A组基础上使用前列地尔进行治疗,对比两组患者治疗效果以及不良反应发生情况。结果:B组患者24h尿蛋白、Scr以及BUN水平均由于A组,差异较大(P<0.05),具有统计学意义。治疗期间B组出现1例注射部位轻微不适。结论:在常规治疗高龄糖尿病合并慢性肾脏疾病的基础上加用前列地尔,治疗效果较好且安全性有保障。
Objective: To investigate the therapeutic efficacy and adverse reactions of alprostadil in elderly diabetic patients with chronic kidney disease. Methods: According to the random number table method, 104 patients with diabetes mellitus and chronic kidney disease treated in our hospital from May 2015 to May 2016 were divided into two groups (A and B), 52 cases each, all of whom were older than 60 years old. Group A For clinical routine treatment, group B was treated with alprostadil on the basis of group A, and the treatment effect and adverse reactions of the two groups were compared. Results: The levels of urinary protein, Scr and BUN in group B were significantly different from those in group A (P <0.05), which was statistically significant. B group during treatment there was 1 case of minor irritation at the injection site. Conclusions: The application of alprostadil on the basis of routine treatment of elderly patients with diabetes mellitus and chronic kidney disease, the treatment effect is better and the safety is guaranteed.