C5aR(CD88)属G蛋白偶联/STR超家族起成员,它至少具两个配体结合位点:一个位于N末端,另一个可能为第二细胞外环上的Glu~(199)。C末端和第三胞浆内环与G蛋白偶联。与C5aR偶联的G蛋白有Giα2、Giα3、G16和Gz,已知涉及的信号传导通路为PI-PLC、Ras/Raf/MAPK、cAMP。C5aR分子及基因结构已阐明,各功能位点、信号传导还有待深入研究。 C5aR (CD88) is a member of the G protein-coupled / STR superfamily that has at least two ligand binding sites: one at the N-terminus and the other at Glu- (199) on the second extracellular loop. The C-terminal and third intracytoplasmic loops are coupled to the G protein. The G proteins coupled to C5aR are Giα2, Giα3, G16 and Gz, and the signaling pathways involved are known to be PI-PLC, Ras / Raf / MAPK, cAMP. C5aR molecules and gene structure have been elucidated, the various functional sites, signaling needs further study.