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目的:探讨基层医院应用固尔苏联合鼻塞持续气道正压通气(NCPAP)防治新生儿呼吸窘迫综合征(NRDS)的疗效及可行性。方法:预防组23例,为胎龄<32周有NRDS高危因素的早产儿,应用固尔苏及NCPAP;治疗组35例,为已发生NRDS的早产儿,应用固尔苏及NCPAP;对照组22例,单用NCPAP治疗。监测治疗前及治疗后1、12、24、48小时的血气分析,对其氧疗时间、住院时间、住院费用、并发症进行分析。结果:治疗组氧疗时间、住院时间、住院费用及并发症均显著低于对照组(P<0.05)。预防组NRDS发生率显著低于对照组,固尔苏治疗后1、12、24、48小时FiO2显著低于固尔苏治疗前(P<0.05)。结论:早期应用固尔苏联合NCPAP能有效预防和治疗NRDS,减少并发症及住院费用,其方法安全可行,适合在有条件的基层医院推广。
Objective: To investigate the curative effect and feasibility of using Gore Su-Su with nasal continuous positive airway pressure (NCPAP) to prevent and treat neonatal respiratory distress syndrome (NRDS) in primary hospitals. Methods: Prevention group of 23 cases, gestational age <32 weeks preterm children with NRDS risk factors, the application of Cure and NCPAP; 35 cases of treatment group, NRDS premature infants, the application of Corsa and NCPAP; control group Twenty-two patients were treated with NCPAP alone. Blood gas analysis was monitored before treatment and 1, 12, 24, 48 hours after treatment, and the oxygen therapy time, hospitalization time, hospitalization expenses and complications were analyzed. Results: The oxygen therapy time, hospitalization time, hospitalization cost and complication in the treatment group were significantly lower than those in the control group (P <0.05). The incidence of NRDS in prevention group was significantly lower than that in control group. The FiO2 at 1, 12, 24 and 48 hours after treatment was significantly lower than that before treatment (P <0.05). Conclusion: The early application of Curel in combination with NCPAP can effectively prevent and treat NRDS, reduce complications and hospitalization costs, and the method is safe and feasible, suitable for promotion in qualified primary hospitals.