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目的 了解贵州少数民族地区的ABO新生儿溶血症发生状况。 方法 抽取苗、侗、布依、水 4个民族共 6 4 5 8名无血缘关系的村民进行ABO血型鉴定 ,并同时进行该地区ABO新生儿溶血症筛查。 结果 发现贵州 4种主要少数民族均有较高的O基因频率 ,少数民族ABO新生儿溶血症典型病例为 5 1‰ (33/ 6 4 5 8) ,城市和农村重症患儿比较 ,差异有显著性 (χ2 =2 3 87,P <0 0 1)。 结论 在广大农村、社区加强孕期保健 ,开展准备生育和早孕妇女的ABO血型鉴定 ,能极大地减少新生儿残疾的发生和死亡率。
Objective To understand the occurrence of hemolytic disease of ABO in Guizhou ethnic minority areas. Methods A total of 6 458 villagers from 4 ethnic groups including Miao, Dong, Buyi and water were enrolled in ABO blood grouping, and ABO neonatal hemolytic disease screening was conducted at the same time. The results showed that all four major ethnic minorities in Guizhou had a higher frequency of O gene. The minority cases of ABO neonatal hemolytic disease were 51% (33/6 458). There was significant difference between urban and rural children with severe disease (Χ2 = 2 3 87, P <0 0 1). Conclusion In the vast rural areas and communities, it is of great significance to reduce the incidence of neonatal disability and mortality by strengthening the pregnancy care and carrying out the ABO blood type identification in women preparing for childbearing and early pregnancy.