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To assess the effects of creatine pyruvate (Cr-Pyr) on lipid and protein metabolism in broiler chickens,a total of 400 1-day-old male birds (Aconred) were randomly allocated to four groups,with each group replicating four times and each replicate involving 25 birds.The broilers were provided with a commercial diet supplemented with Cr-Pyr at 0,1,5,or 10％ of the diet,respectively,for a period of 3 wk ad libitum (from 22 to 42 d).In the present study,body weight (BW) and average daily gain (ADG) of broilers decreased in 10％ Cr-Pyr group (P＜0.01),whereas the relative leg and pectoral muscle weights were significantly higher than they were in the control group (P＜0.05).5 or 10％ Cr-Pyr of diets decreased the abdominal fat rate (AFR,abdominal fat/live weight) of the broilers.The serum or hepatic triglyceride (TG) concentrations were significantly lower in the 5 and 10％ groups (P＜0.01).In contrast,Cr-Pyr caused a marked increase in the serum nonesterified fatty acid (NEFA),high-density lipoprotein cholesterol (HDL-C) and creatine kinase (CK) concentrations (P＜0.01).Supplementation with Cr-Pyr (5 and 10％) in the diet also increased glucagons (GLU),insulin (INS) or leptin (LEP) contents (P＜0.01).The expression of hepatic peroxisomal proliferators-activated receptor α (PPAR-α) and carnitine palmitoyl transferase-I (CPT-I),muscle insulin-like growth factor I (IGF-I) were significantly elevated and myostatin mRNA level was reduced in the 5 and 10％ groups (P＜0.05).It was found that supplementation with 5％ Cr-Pyr improves both lipid and protein metabolism by regulating various metabolic parameters of broilers,while not adversely affects growth performance in broiler chickens.