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目的:应用红外热成像系统对资冲颗粒药物靶向性进行动态评价研究。方法:募集6名受试者,分别在其服药前0 min及服药后的30、70、100、130、160 min,采用红外热成像系统对每位受试者采集全身10~11幅热像图,完成共计36例次的扫描后,对双肾区、双侧卵巢区、下腹区、子宫膀胱区、督脉区、神阙区、足部区、心脏区、大脑区、眼底区共13个区位的热值进行数据分析。结果:(1)服用资冲颗粒后第30~70 min及第130~160 min,与生殖相关区位(双肾区、双卵巢区、下腹区、子宫膀胱区)热值及与阳气相关区位(督脉区、神阙区、足部区)热值均上升;(2)第100 min时心脏区、眼底区双侧热值差异值最低,第160 min时大脑区双侧热值差异值最低。结论:资冲颗粒除提高生殖相关区位代谢及提升全身阳气外,还可明显缓解心脏、大脑、眼底血供,提示资冲颗粒具有多系统、多环节、多靶点整体调节作用。
OBJECTIVE: To study the dynamic evaluation of Zhibeng granules by using infrared thermal imaging system. Methods: Six subjects were enrolled, and 10 ~ 11 whole body images were collected from each subject by using the infrared thermal imaging system at 0 min before taking the drug and 30, 70, 100, 130 and 160 min after taking the drug. After the completion of a total of 36 cases of scans, a total of 13 cases of bilateral renal area, bilateral ovary area, lower abdomen area, uterine bladder area, Du meridian area, Shenque area, foot area, heart area, brain area, fundus area The location of the calorific value for data analysis. Results: (1) After 30 ~ 70 min and 130 ~ 160 min after taking Zi Chong Granules, the calorific values of the reproductive-related sites (double kidney area, double ovary area, lower abdominal area and uterine bladder area) (Du region, Shenque area, foot area) caloric value increased; (2) The first 100 min, the heart area, the fundus of both sides of the lowest calorific value difference, the first 160 min when the bilateral brain heat value difference lowest. Conclusion: In addition to improving the reproductive-related location metabolism and enhancing the body yang, ZIZO granules can obviously relieve the blood supply to the heart, brain and fundus, suggesting that Zizhixi granules has the functions of multiple systems, multiple links and multiple targets.