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目的研究江西地区慢性肾小球肾炎尿毒症与HLA-DRB1的相关性,发现易感基因和保护基因,为CGN的临床治疗、预后及预防措施提供了理论依据。方法对本中心进行肾移植配型检测的637例慢性肾小球肾炎尿毒症患者的HLA-DRB1基因分型与中国造血干细胞库江西健康捐献者的基因分型进行对比分析,并计算HLA-DRB1基因与肾移植的发病风险。结果 HLA-DRB1座位共检出13个等位基因,患者组HLA-DRB1等位基因中,DRB1*04、DRB1*11、DRB1*12、DRB1*13等位基因的频率患者组明显高于对照组(P<0.05),DRB1*07、DRB1*16患者组明显低于对照组(P<0.05)。结论 HLA-DRB1*04、DRB1*11、DRB1*12和DRB1*13可能是江西地区慢性肾小球肾炎尿毒症的易感基因,HLA-DRB1*07、*16可能是江西地区慢性肾小球肾炎尿毒症保护基因。
Objective To investigate the relationship between uremia and HLA-DRB1 in patients with chronic glomerulonephritis in Jiangxi Province and to find out the susceptibility genes and protective genes in order to provide a theoretical basis for the clinical treatment, prognosis and preventive measures of CGN. Methods The HLA-DRB1 genotyping in 637 patients with chronic glomerulonephritis uremic patients and the genotyping of Chinese hematopoietic stem cell-pooling healthy donors in China were compared and the HLA-DRB1 gene Risk of kidney transplant. Results Thirteen alleles were detected in HLA-DRB1 loci. Among HLA-DRB1 alleles, frequencies of DRB1 * 04, DRB1 * 11, DRB1 * 12 and DRB1 * 13 alleles were significantly higher in patients with HLA- Group (P <0.05), DRB1 * 07, DRB1 * 16 patients was significantly lower than the control group (P <0.05). Conclusion HLA-DRB1 * 04, DRB1 * 11, DRB1 * 12 and DRB1 * 13 may be susceptible genes of chronic glomerulonephritis in Jiangxi area. HLA-DRB1 * 07 and * 16 may be the markers of chronic glomerular Nephritis uremic protection gene.