特发性血小板减少性紫搬(ITP)通常是指骨髓正常而不伴有全身性疾病的血小板减少症。本病的血小板减少是由于与体液或细胞免疫机理有关的血小板寿命缩短所致。通过血小板凝集试验和补体结合试验,在一些ITP患儿血清中已检测到抗血小板抗体。Dixon等报导了血小板结合抗体直接定量测定法,此法灵敏、特异,但操作困难。作者使用5-羟色胺释放试验,研究儿童ITP病例的血小板减少期和恢复后血清中血小板抗体。其原理 Idiopathic thrombocytopenia (ITP) usually refers to thrombocytopenia with normal bone marrow without systemic disease. The thrombocytopenia of this disease is due to the shortening of the platelet life span associated with humoral or cellular immune mechanisms. Antiplatelet antibodies have been detected in serum of some ITP children through platelet aggregation tests and complement fixation tests. Dixon et al. Reported a direct and quantitative assay of platelet-bound antibody that is sensitive and specific but difficult to manipulate. The authors used serotonin release to study thrombocytopenia in children with ITP and serum platelet antibodies after recovery. Its principle