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目的:探讨肠毒清口服液对全身炎症反应综合征(SIRS)大鼠血清及肺泡灌注液中炎性细胞因子的影响。方法:将SD大鼠随机分为正常组、A模型组、A低剂量组、A中剂量组、A高剂量组及B模型组、B低剂量组、B中剂量组、B高剂量组9组,每组8只,用腹腔注射酵母多糖悬浊液(ZPS)法造SIRS模型,正常组、模型组及肠毒清口服液各剂量组分别给予NS和不同浓度肠毒清口服液灌胃,连续3天,2次/天,末次给药后第3天处死大鼠,检测大鼠血清及肺泡灌注液中炎性细胞因子的水平。结果:A、B各组血清中炎性因子水平略高于正常组;A、B模型组与低、中、高剂量组各炎性因子无统计学意义;B低、中、高剂量组的肺泡灌注液中炎性因子水平略高于A组,但无统计学意义。结论:高剂量的肠毒清口服液可通过减轻炎性因子的释放,缓解750 mg/kgZPS导致的SI RS症状。
Objective: To investigate the effect of Changduqing oral liquid on inflammatory cytokines in serum and alveolar perfusion fluid of systemic inflammatory response syndrome (SIRS) rats. Methods: SD rats were randomly divided into normal group, A model group, A low dose group, A middle dose group, A high dose group and B model group, B low dose group, B middle dose group, B high dose group Group, with 8 rats in each group. SIRS model was made by intraperitoneal injection of ZPS. The normal group, model group and each dose of enterotoxin oral solution were given NS and different concentrations of enterotoxin oral solution , For 3 consecutive days, 2 times / day, rats were sacrificed on the 3rd day after the last administration, and the levels of inflammatory cytokines in serum and alveolar perfusate were detected. Results: The serum levels of inflammatory cytokines in group A and group B were slightly higher than those in normal group. There was no significant difference in each group between model group A, B and the low, middle and high dose groups. The level of inflammatory cytokines in alveolar perfusion fluid was slightly higher than that in group A, but there was no statistical significance. CONCLUSION: High dose of enterotoxin can relieve SI RS symptoms caused by 750 mg / kg ZPS by reducing the release of inflammatory cytokines.