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为了研究探讨食管贲门粘膜下癌的非手术治疗方法，选择３１例不适宜手术或拒绝手术，而同意接受内镜ＮｄＹＡＧ激光照射加局部注射化疗药物治疗的食管或贲门粘膜下癌患者，采用输出功率３０Ｗ、脉冲时间１ｓ、光距０．５ｃｍ～１．０ｃｍ的ＮｄＹＡＧ激光器治疗。以准接触或非准接触连续扫描方式进行照射后，又用５－Ｆｕ２５０ｍｇ和丝裂霉素２ｍｇ对病灶四周及中央分点注射。经１～４次治疗后，癌细胞消失，无穿孔、出血等并发症。随访６月～１２月，全部病例均未发现癌细胞。初步结果显示：该方法有效，安全，痛苦小，费用低，可达到甚至优于外科手术的疗效，是不适宜手术或拒绝手术病人，特别是高龄体弱者的首选治疗方法
In order to study the non-surgical treatment of submucosal carcinoma of the esophagus, 31 patients with esophageal or cardiac submucosal cancer who agreed with endoscopic NdYAG laser irradiation and local injection chemotherapy were selected for output power. 30W, pulse time 1s, light distance 0.5cm ~ 1.0cm NdYAG laser treatment. After irradiating with quasi-contact or non-quasi-contact continuous scans, 5-Fu250mg and mitomycin 2mg were used to inject around the lesion and at the center. After 1 to 4 treatments, the cancer cells disappeared without complications such as perforation or hemorrhage. During follow-up from June to December, no cancer cells were found in all cases. Preliminary results show that this method is effective, safe, painless, low cost, can achieve or even better than surgical treatment, is not suitable for surgery or rejection of surgery patients, especially the treatment of choice for the elderly and the infirm