Since United Nations adopted the global Sustainable Development Goals(SDGs) for the next15 years(2016-2030), sustainable development will further become a core concept and main principle to guide global and national economic and social development. According to this background, strengthening the integrative research on the theories and methodologies of sustainable development has been a strategically important mission. This article provided an analytic framework for sustainability science, named the object-subject-process(OSP) framework for examining the key issues encountered during the theoretical research and policy analysis. This study emphasized that, on the object dimension, sustainable development means to seek for economic and social development within biophysical limits of the earth and the relationship of environment, society, and economy should be containing and complementary rather than parallel and substitute; on the process dimension, sustainable development should adopt both the responsive and proactive strategies for the whole process management which employing pressure-state-response(PRS) model rather than dealing with one part of them; on the subject dimension, sustainable development research should involve the key stakeholders who are kind of collaborate governance rather than separate each other. From the perspective of sustainability science, green economy was utilized as a case study to explore the issues of object, process and subject and also the significance of green economy was discussed in this study. Since United Nations adopted the global Sustainable Development Goals (SDGs) for the next 15 years (2016-2030), sustainable development will further become a core concept and main principle to guide global and national economic and social development. According to this background, strengthening the integrative research on the theories and methodologies of sustainable development has been a strategically important mission. This article provides an analytic framework for sustainability science, named the object-subject-process (OSP) framework for examining the key issues encountered encountered the theoretical research and policy analysis. This study emphasized that, on the object dimension, sustainable development means to seek for economic and social development within biophysical limits of the earth and the relationship of environment, society, and economy should be containing and complementary rather than parallel and substitute; on the process dimension, sustainable development should adopt both the responsive and proactive strategies for the whole process management employing employing-pressure-state-response (PRS) model rather than dealing with one part of them; on the subject dimension, sustainable development research should involve the key stakeholders who are kind of from the perspective of sustainability science, green economy was utilized as a case study to explore the issues of object, process and subject and also the significance of green economy was discussed in this study.