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目的探讨无创通气联合纳洛酮治疗慢性呼吸衰竭并肺性脑病的临床疗效。方法 180例慢性呼吸衰竭并肺性脑病患者随机分为2组,其中对照组单纯应用无创通气,观察组在对照组的基础上使用纳洛酮注射剂,比较2组临床疗效。结果观察组显效率67.78%,对照组为18.89,差异有统计学意义(Z=3.445,P<0.05);2组治疗前后pH值、PaCO2、PaO2均明显改善,差异均有统计学意义(P<0.05)。结论无创通气联合纳洛酮治疗慢性呼吸衰竭并肺性脑病具有显著疗效。
Objective To investigate the clinical effects of noninvasive ventilation combined with naloxone on chronic respiratory failure and pulmonary encephalopathy. Methods One hundred and eighty patients with chronic respiratory failure and pulmonary encephalopathy were randomly divided into two groups. The control group received noninvasive ventilation only. The observation group received naloxone injection on the basis of the control group, and the clinical efficacy was compared between the two groups. Results The effective rate was 67.78% in the observation group and 18.89 in the control group, the difference was statistically significant (Z = 3.445, P <0.05); before and after treatment, the pH value, PaCO2 and PaO2 were significantly improved <0.05). Conclusion Non-invasive ventilation combined with naloxone in the treatment of chronic respiratory failure and pulmonary encephalopathy has a significant effect.