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慢性实验中,电刺激清醒家兔内脏大神经模拟内脏痛刺激,以前肢回缩反应(Withdrawreaction,WR)为痛反应指标,探讨了背海马内微量注射埃托啡对WR阈值的影响。结果表明:(1)单侧海马内微量注射埃托啡2μg/2μl,可显著提高兔WR阈值,作用维持20min。(2)该效应对剂量有依从关系,并能被静脉注射0.4mg/kg纳洛酮拮抗。(3)海马内微量注射埃托啡后,WR阈值提高和呼吸频率抑制呈分离现象。提示:海马内阿片受体可能参与内脏痛的镇痛作用。
In the chronic experiment, electrical stimulation of visceral nerves in awake rabbits simulates visceral pain stimulation. Using Withdrawreaction (WR) as a pain response index, we investigated the effect of microinjection of etoposide on WR threshold in the dorsal hippocampus. The results showed that: (1) Microinjection of 2μg / 2μl of etoposide into unilateral hippocampus significantly increased the rabbit WR threshold and maintained the effect for 20min. (2) This effect is dose-dependent and can be antagonized by intravenous injection of 0.4 mg / kg naloxone. (3) After the microinjection of etanercept in the hippocampus, the increase of WR threshold and the suppression of respiration rate were separated. Tip: Hippocampal opioid receptors may participate in the analgesic effect of visceral pain.