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采用大鼠四氧嘧啶糖尿病模型，观察糖尿病对心脏缺血／再灌注性室颤的累计持续时间（ＶＦｔ）、发生率（ＶＦｒ）及缺血预处理（ＩＰ）后心脏缺血保护作用的影响。结果：糖尿病大鼠与非糖尿病大鼠相比再灌期ＶＦｒ明显降低（４６％比９３％，Ｐ＜０．０５），缺血期室颤出现时间延迟〔（１４．３６±３．６７）ｓ比（５．８１±１．０２）ｓ，Ｐ＜０．０１〕；缺血１０ｍｉｎＶＦｔ〔（０．４３±０．２５）ｓ比（３９．００±２６．２７）ｓ，Ｐ＜０．０５〕及再灌期ＶＦｔ〔（５．００±２．９７）ｓ比（２３４．０７±６４．６８）ｓ，Ｐ＜０．０１〕均显著缩短，提示早期糖尿病大鼠心电稳定性较好。糖尿病大鼠心肌缺血预处理对心脏缺血再灌期的ＶＦｒ及ＶＦｔ皆无影响，而缺血１０ｍｉｎ的ＶＦｔ较糖尿病非预处理组大鼠增加，说明早期糖尿病时心脏缺血的自身保护作用有所减弱。
The alloxan diabetic model was used to observe the effects of diabetes mellitus (VFt) on the duration of ischemic / reperfusion VF and the protective effect of ischemic preconditioning (IP) . Results: Compared with non-diabetic rats, VFr in reperfusion group was significantly lower (46% vs 93%, P <0.05), and the duration of ischemic VF was delayed (14.36 ± 3.67) s (P <0.05), s (P <0.05), P <0.01 (P <0.01). The ischemic 10minVFt 〔(0.43 ± 0.25) s (39.00 ± 26.27) s, P <0. 05〕 and reperfusion VFt 〔(5.00 ± 2.97) s (234.07 ± 64.68) s, P <0.01〕 were significantly shortened, suggesting that early diabetic rats ECG stability than it is good. Myocardial ischemic preconditioning in diabetic rats had no effect on VFr and VFt during ischemia and reperfusion, while VFt at 10 min after ischemia increased compared with non-pretreated diabetic rats, indicating the protective effect of heart ischemia on early diabetic Weakened.