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目的:探讨大肠癌组织胰岛素样生长因子-Ⅱ(IGF-Ⅱ)和胰岛素样生长因子-Ⅰ受体(IGF-ⅠR)的表达情况和二者的相关性。方法:应用免疫组织化学方法检测50例大肠癌组织、20例大肠腺瘤和50例正常大肠黏膜IGF-Ⅱ和IGF-ⅠR的表达情况。结果:大肠正常黏膜、腺瘤和大肠癌IGF-Ⅱ、IGF-ⅠR的阳性表达率逐渐升高(P<0.05);并且,大肠癌组织IGF-Ⅱ与IGF-ⅠR的表达呈正相关(r=0.585,P<0.01)。结论:IGF-Ⅱ和IGF-ⅠR与大肠癌的发生发展密切相关。
Objective: To investigate the expression of insulin-like growth factor-Ⅱ (IGF-Ⅱ) and insulin-like growth factor-Ⅰ receptor (IGF-ⅠR) in colorectal carcinoma and their relationship. Methods: Immunohistochemistry was used to detect the expression of IGF-Ⅱ and IGF-ⅠR in 50 cases of colorectal carcinoma, 20 cases of colorectal adenoma and 50 cases of normal colorectal mucosa. Results: The positive rates of IGF-Ⅱ and IGF-ⅠR in colorectal mucosa, adenoma and colorectal cancer increased gradually (P <0.05), and the expressions of IGF-Ⅱ and IGF-ⅠR in colorectal carcinoma were positively correlated (r = 0.585, P <0.01). Conclusion: IGF-Ⅱ and IGF-ⅠR are closely related to the occurrence and development of colorectal cancer.