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肠球菌是血液感染分离到的第三大常见病原体。肠球菌对多种抗生素日益增强的耐药性使得治疗方法的选择更为有限,因此,需要替代疗法。虽然粪肠球菌具有许多毒力因子,但是只有聚集物质和磷壁酸样荚膜多糖用于疫苗研制的潜能得到评估。抗纯化荚膜多糖抗体具有高度调理性,主动免疫荚膜多糖和被动免疫抗荚膜多糖抗体均能保护小鼠免受细菌感染。由于粪肠球菌荚膜血清型有限,因此其荚膜多糖可能是研制结合疫苗的候选抗原。
Enterococci are the third most common pathogens isolated from bloodstream infections. The increasing resistance of enterococci to multiple antibiotics has made the choice of treatment options more limited and, as a result, alternative therapies are needed. Although Enterococcus faecalis has many virulence factors, only the potential of aggregates and tetrapeptide polysaccharides for vaccine development has been evaluated. Anti-purified capsular polysaccharide antibodies have a high degree of conditioning, active immune capsular polysaccharide and passive immunized anti-capsular polysaccharide antibodies can protect mice from bacterial infection. Due to the limited serotype of Enterococcus faecalis, its capsular polysaccharide may be a candidate antigen for the development of a conjugate vaccine.