论文部分内容阅读
抗疟中草药青蒿素,是近来研制的一种新类型结构的抗疟药。在临床验证中,具有高效、速效,低毒的优点,但复发率高为其主要缺点。我们通过将青蒿素与氯喹、乙胺嘧啶等已知作用原理的抗疟药进行对比,观察药物对鼠疟原虫形态学的变化,从而推测青蒿素对原虫的作用类型,为抗青蒿素复发问题提供线索。实验分为青蒿素、氯喹及乙胺嘧啶三组,于给药后6、10、16、24、48小时分别涂血片一次,每次均涂两套血片。一套用吉氏染液染色,另一套用0.5%曙红染色,以观察色素的大小与排列。实验表明青蒿素对原虫形态变化与氯喹近
The antimalarial Chinese herbal medicine, artemisinin, is a new type of structural antimalarial medicine recently developed. In clinical verification, it has the advantages of high efficiency, quick response, and low toxicity, but its high recurrence rate is its major drawback. We compared the artemisinin with known antimalarial drugs such as chloroquine and pyrimethamine to observe the changes in the morphology of P. falciparum and to speculate the type of action of artemisinin on the protozoan. Recurrence problems provide clues. The experiment was divided into three groups: artemisinin, chloroquine and pyrimethamine. The blood tablets were applied at 6, 10, 16, 24, and 48 hours after administration, and two blood tablets were applied each time. One set was stained with Giemsa stain and the other set was stained with 0.5% eosin to observe the size and arrangement of the pigments. Experiments show that artemisinin changes the morphology of protozoa with chloroquine