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在英国药典(BP)和印度药典(IP)中,acetomena-phthone(维生素K_4)的测定是基于水解成对苯二酚衍生物以后用硫酸铈铵进行氧化还原滴定,该法费时且需大量样品,并在滴定前需要小心处理以防对苯二酚衍生物的空气氧化。本文报道的方法是测定维生素K_4的乙酰基,为利用维生素K_4经羟氨基化转变成乙酰异羟肟酸(Aceto—hydroxamic acid),在酸性条件下,与三氯化铁形成红
In the British Pharmacopoeia (BP) and Indian Pharmacopoeia (IP), the determination of acetomena-phthone (vitamin K_4) is based on the redox titration with ceric ammonium sulfate after hydrolysis to hydroquinone derivatives, which takes time and requires a large amount of sample , And care needs to be taken before titration to prevent air oxidation of hydroquinone derivatives. The method reported in this paper is to determine the acetyl group of vitamin K_4, which is converted into aceto-hydroxamic acid by hydroxy-amidation of vitamin K_4 and forms red with ferric chloride under acidic condition