免疫增殖性小肠病(简称IPSID)包括多种疾病,其共同表现为腹泻、体重减轻、腹痛和杵状指趾等,据认为是近端小肠粘膜和肠系膜淋巴结有严重的淋巴浆细胞弥漫性浸润所效。这些浸润细胞可合成异常的α-重链免疫球蛋白,或形成可发展为原发性小肠-肠系膜淋巴瘤的基质。此病在发达国家中罕见,但在发展中国家颇流行。本病亦称地中海淋巴瘤,20年来对本病的了解对于认识人类淋巴网状系统肿瘤很有关系,其重要性可与Burkitt’s淋巴瘤相比。IPSID最终可从一良性且可治愈的疾病演变为恶性,因而对其早期作出诊断和治疗极为重要。病理过程 IPSID常累及十二指肠第二、三、四段以及上段空肠。只累及回肠或累及整个小肠者罕见,而扩展到胃或大肠者更为罕见。肠道病变 Immune proliferative small bowel disease (IPSID) includes a variety of diseases, which together manifest as diarrhea, weight loss, abdominal pain and clubbed toe, etc. It is thought that the proximal small intestinal mucosa and mesenteric lymph nodes have severe diffuse infiltration of lymphocytes Effective. These infiltrating cells can synthesize abnormal alpha-heavy chain immunoglobulins or form a matrix that can develop into primary intestinal mesentery lymphoma. The disease is rare in developed countries, but quite prevalent in developing countries. The disease is also known as lymphatic disease of the Mediterranean, 20 years of understanding of the disease is very important for the understanding of human lymphoid neoplasms, its importance compared with Burkitt’s lymphoma. IPSID can eventually evolve from a benign and curable disease to malignancy, making it extremely important for early diagnosis and treatment. Pathological process IPSID often affects the second, third and fourth segments of the duodenum and upper jejunum. It is rare to involve only the ileum or the entire small intestine, but it is even more rare to spread to the stomach or large intestine. Intestinal lesions