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目的:观察2型糖尿病(T2DM)患者肺通气功能以及弥散功能的改变情况,分析不同病程、不同并发症对肺功能的影响。方法:对82例T2DM患者及39例健康人进行肺通气功能和弥散功能的测定,进行对比分析。结果:T2DM组,用力肺活量(FVC)、肺总量(TLC)、最大通气量(MVV)、1s用力呼气量(FEV1)占预计值百分比、FEV1/FVC和肺一氧化碳弥散量(DLCO)、单位肺泡容积的一氧化碳弥散量(DLCO/VA)及占预计值百分比均低于对照组(P<0.05)。病程>10年T2DM组VC、FEV1、MVV、TLC、DLCO和DLCO/VA与病程<10年T2DM组比较,差异有统计学意义(P均<0.05)。T2DM有并发症组DLCO和DLCO/VA均明显低于无并发症组(P<0.05)。结论:T2DM患者存在肺通气功能及弥散功能损害,肺弥散功能损害主要与T2DM病程有关,早期监测肺功能指标对T2DM患者肺损伤的预防和治疗有一定意义。
Objective: To observe the changes of pulmonary function and diffusion function in patients with type 2 diabetes mellitus (T2DM) and analyze the influence of different course and complications on pulmonary function. Methods: 82 cases of T2DM patients and 39 healthy people were measured pulmonary function and diffusion function, comparative analysis. Results: In T2DM group, FVC, TLC, MVV, FEV1, percentage of predicted value, FEV1 / FVC and DLCO, The volume of carbon monoxide per unit volume of alveolar volume (DLCO / VA) and the percentage of predicted value were lower than the control group (P <0.05). The duration of disease> 10 years, T2DM group, VC, FEV1, MVV, TLC, DLCO and DLCO / VA and duration of <10 years T2DM group, the difference was statistically significant (P all <0.05). DLCO and DLCO / VA in patients with complications of T2DM were significantly lower than those without complications (P <0.05). CONCLUSION: There is pulmonary ventilation and diffuse dysfunction in T2DM patients. The impairment of pulmonary diffuse function is mainly related to the course of T2DM. Early monitoring of pulmonary function indicators is of great significance in the prevention and treatment of lung injury in T2DM patients.