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目的检测血管内皮生长因子C(VEGF-C)在食管正常上皮、食管上皮非典型增生及食管鳞状细胞癌(鳞癌)组织中的表达,探讨VEGF-C与食管鳞癌发生、淋巴结转移和发展的相互联系。方法采用免疫组织化学S-P法检测25例正常食管、70例食管鳞状上皮非典型增生、55例食管鳞癌组织中VEGF-C的表达。结果 VEGF-C在正常食管鳞状上皮、食管鳞状上皮非典型增生及食管鳞癌组织中的表达依次增高,差异有统计学意义(P<0.05),无淋巴结转移的食管癌组织中VEGF-C的阳性表达明显低于有淋巴结转移病例(P<0.05),VEGF-C在低分化鳞癌组织中的表达明显高于中高分化鳞癌组织(P<0.05),但与临床分期无关。结论 VEGF-C蛋白表达与食管鳞癌发生、发展及淋巴转移有关。
Objective To detect the expression of vascular endothelial growth factor C (VEGF-C) in esophageal normal epithelium, esophageal epithelial atypical hyperplasia and esophageal squamous cell carcinoma (squamous cell carcinoma), and to investigate the relationship between VEGF-C and esophageal squamous cell carcinoma, lymph node metastasis and Development of interrelatedness. Methods Immunohistochemical S-P method was used to detect the expression of VEGF-C in 25 normal esophageal tissues, 70 esophageal squamous epithelial atypical hyperplasia and 55 esophageal squamous cell carcinoma tissues. Results The expression of VEGF-C in normal esophageal squamous epithelium, esophageal squamous epithelial atypical hyperplasia and esophageal squamous cell carcinoma increased in turn, the difference was statistically significant (P <0.05), no lymph node metastasis of esophageal cancer tissue VEGF- C was significantly lower than that in patients with lymph node metastasis (P <0.05). The expression of VEGF-C in poorly differentiated squamous cell carcinoma was significantly higher than that in moderately well-differentiated squamous cell carcinoma (P <0.05), but not related to clinical stage. Conclusion The expression of VEGF-C is associated with the occurrence and development of esophageal squamous cell carcinoma and lymphatic metastasis.