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肾病患者肾脏组织中存在脂蛋白,但是否存在载脂蛋白(apo),在组织学上尚未得到证实。作者通过免疫荧光技术检测肾脏活检标本中的apoB和apoE,以期找到apo和肾脏疾病临床特点及组织学特点之间的关系。病人和方法:(病人49例,其中35例原发性肾小球疾病,13例继发性肾小球疾病,1例肾小管间质性肾炎。年龄10～62岁(平均37.2岁),均为持续性蛋白尿和/或血尿。从发现尿异常到行肾活检时间为1-17年(平均3.6年)。用Zeiss Axiophot荧光照相显微镜和光镜观察肾活检标本,并按荧光镜下所见将病人分为4组:1组apoB(-)apoE(-);2组
Lipoproteins are present in kidney tissue of patients with nephropathy, but the presence or absence of apolipoprotein has not been confirmed histologically. The authors examined apoB and apoE in renal biopsy specimens by immunofluorescence in order to find the relationship between apo and clinical features and histological features of renal disease. Patients and Methods: (49 patients, including 35 cases of primary glomerular disease, 13 cases of secondary glomerular disease, 1 case of tubulointerstitial nephritis, aged 10 to 62 years (mean 37.2 years) All of them were persistent proteinuria and / or hematuria.The time from finding the abnormal urine to performing the renal biopsy was from 1 to 17 years (average 3.6 years) .The renal biopsy specimens were observed with Zeiss Axiophot fluorescence microscope and light microscope, See patients were divided into 4 groups: a group of apoB (-) apoE (-); 2 groups